DACIHEP ( DACLATASVIR)IS A NS5A REPLICATION COMPLEX INHIBITOR.
Dacihep ( Daclatasvir)is specifically indicated for use with sofosbuvir for the treatment of patients with chronic
hepatitis C virus
(HCV) of genotype 1, 3, or 4 infections.
The other medications used in combination include sofosbuvir, ribavirin, and interferon, vary depending on the virus type and whether the person has cirrhosis. Dacihep ( Daclatasvir) stops HCV viral RNA replication and protein translation by directly inhibiting HCV protein NS5A. NS5A is critical for HCV viral transcription and translation, Dacihep ( Daclatasvir)is supplied as tablets for oral administration.
Dose modifications are made with concomitant use of daclatasvir and drugs that affect CYP3A or p-gp. When taking daclatasvir with non-nucleoside reverse transcriptase inhibitors, the dose of daclatasvir is increased to overcome CYP3A induction. The dose for daclatasvir should be lowered when taking with antifungals, such as ketoconazole.
Currently, there are no required dosage adjustments with concurrent use of daclatasvir and immunosuppressants, narcotic analgesics, antidepressants, sedatives, and cardiovascular agents. Concurrent use with amiodarone, sofosbuvir and daclatasvir has may result in an increased risk for serious slowing of the heart rate. Common side effects with sofosubvir and daclatasvir include headache, feeling tired, and nausea.
With daclatasvir, sofusbivir, and ribavirin the most common side effects are headache, feeling tired, nausea, and red blood cell breakdown. It should not be used with St. John's wort, rifampin, or carbamazepine. It works by inhibiting the HCV protein NS5A. It is on the World Health Organization's List of Essential Medicines
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